Its applications range from bulk production of products, like poly lactic acid pla, in industries to simple household. Production of dlactic acid by the fermentation of orange. The lactic acid can also be recovered as tertiary alkaline salt. One of the advantages of using a byproduct of sugar production for lactic acid production is that its industrial plant can be easily integrated into a mill following the biorefinery concept. Lactic acid production by new lactobacillus plantarum lmism6. The application of conventional polylactic acid pla is limited due to insufficient thermal properties. The main problem is the limited knowledge of dlactic acid dla production. Mar 12, 2007 lactic acid industrial production free download as pdf file.
The first vinegar was spoiled wine, consisting the latin word acetum means sour or sharp wine. Industrial production of high molecular weight polylactic. Lactic acid, a widely used chemical, exists as a mixture of d and l isomers when synthesized through a chemical route. In lactic acid bacteria lab, production of polysaccharides has long been associated with the technological, functional and healthpromoting benefits of these microorganisms. Separation and purification technologies for lactic acid. Industrial production of acetone, butanol, butanodiol substrates for rubber production 1 1930 discovery of biotechnological method of organic acids production citric and gluconic acid 1, 5 1940s industrial production of organic acids 1 1950s industrial penicillin production first highcost and hightech process. Continuous lactic acid fermentation of whey to produce a ruminant feed supplement high in crude protein. The global interest in this product is due to its use for the synthesis of numerous chemical compounds, including polylactic. Melt processing is the main technique used for mass production of pla products for the medical, textile, plasticulture, and. The current status and future expectations in industrial production. A number of industrial byproducts or wastes have been evaluated as. For the last five decades, pla has been mainly used in biomedical applications.
Production, optimization and characterization of lactic. Lactic acid producing bacteria are broadly categorized into two types. The biorefinery concept can be applied to lactic acid production from sbp, as it has been done for sugar and ethanol production. Commercial production of lactic acid linkedin slideshare. As a result, the focus for improving strains for microbial fermentation is on classical strain improvement methods. Production, optimization and characterization of lactic acid.
Pdf industrial production of lactic acid and its applications. After fermentation, the broth needs to be purified to obtain pure lactic acid for further uses. The application of conventional poly lactic acid pla is limited due to insufficient thermal properties. Exopolysaccharides epsproducing lactic acid bacteria lab are industrially important microorganisms in the development of functional food products and are used as starter cultures or coadjutants to develop fermented foods.
Life cycle inventory and impact assessment data for 2014. In 2009, lactic acid was produced predominantly 7090% by fermentation. Biotechnology and bioengineering 1975, 17 7, 9971018. Production of polylactic acid chemical engineering page 1. Lactic acid production by new lactobacillus plantarum lmism6 grown in molasses.
Polylactic acidmass production, processing, industrial applications. Kite, a gilead company, santa monica, ca 90404, usa. Dec 29, 2014 this industrial microbiology lecture explains about the industrial production of lactic acid. Lactic acid bacteria for industrial chemical production michael 2 sauer,1,2,3, hannes russmayer,1,2 reingard 1,2 grabherr, clemens k. Its applications range from bulk production of products, like. The environmental performance of lactic acid is summarised in table 1 based on the available relevant lca data for lactic acid production using different raw materials corn, sugar cane and corn stover, through the conventional lactic acid purification process. Lactic acid in food products usually serves as either as a ph regulator or as a preservative.
Introduction lactic acid based polymers by polycondensation lactic acid based polymers by chain extension lactic acid based polymers by ring. Lactic acid industrial production free download as pdf file. Lactic acid is one the most interesting monomer candidates to replace some petroleum based monomers. The current status and future expectations in industrial. Quoted in prescott sc, dunn cg 1959 the production of lactic acid by fermentation. The production of organic acids discussed here includes those which are currently. Production of important organic acids by fermentation. Sanchezriera biotechnical resources, wisconsin, usa keywords. Ingeo is prepared through the polymerization of lactide to make polylactide polymer. Request pdf industrial production of lactic acid lactic acid ranks among the highvolume chemicals produced microbially, with an annual. Aug 29, 2014 as a result, the focus for improving strains for microbial fermentation is on classical strain improvement methods.
Journal of chemical and pharmaceutical research, 2015, 7. Production of bioactive peptides from lactic acid bacteria. Lactic acid can be produced by fermentation or chemical synthesis. Hence in the fermentation broth, organic solvent is added to get salts of lactic acid which is decomposed and free acid is released. A simple method to reduce both lactic acid and ammonium production in industrial animal cell culture nathaniel w. Lactic acid is one of the most commercially useful hydroxycarboxylic acids.
Sanchezriera encyclopedia of life support systems eolss production of organic acids f. Lactic acid production from sugarcane bagasse hydrolysates. In fermentation, lactic acid is the endpoint of their energy metabolism. Acetic acid, citric acid, gluconic acid, itaconic acid, lactic acid, propionic acid, pyruvic acid, succinic acid contents 1. Fermentation free fulltext production of dlactic acid. Pdf biotechnological valorization of agro industrial and. Industrial production of l lactic acid, which in polymerized form as poly lactic acid is widely used as a biodegradable plastic, has been attracting worldwide attention. Production of lactic acid by fermentation is advantageous because renewable and low cost raw materials can be used as substrates.
The current status and future expectations in industrial production of lactic acid by lactic acid bacteria 617 although it is a common practice to divide lab into homo and heterofermentative strains, the division is not that straightforward as the actual metabolism is dependent on both the. Industrial production of high molecular weight polylactic acid. These bacteria are employed in food or feed preservation. After final purification, the lactic acid enters the lactideingeo manufacturing process. This industrial microbiology lecture explains about the industrial production of lactic acid. Industrial production with the microbiological route was started when the acids were identified as. Contributory roles of two l lactate dehydrogenases for l. The microorganisms being used for lactic acid fermentation, the raw materials reported, the. Lactic acid e270 is also used in a wide range of food applications such as bakery products, beverages, meat products, confectionery, dairy products, salads, dressings, ready meals, etc. The art of strain improvement of industrial lactic acid. Melt processing is the main technique used for mass production of pla products for the medical, textile, plasticulture, and packaging industries. Lactic acid has the potential of becoming a very large volume, commoditychemical. Applications of lactic acid fermentation are found in dairy industry, production of wine and cider, production of fermented vegetable products and meat industry.
The actions of lab are species and strain specific, and depend on the amount of bacteria available in the gastrointestinal tract. A simple biorefinery concept to produce 2glactic acid. The main problem is the limited knowledge of d lactic acid dla production. Poly lactic acid mass production, processing, industrial applications, and end of life. Lactic acid properties, applications and production. Although some acids have been produced for some time and indepth knowledge of these microbial production processes has been gained, further microbial production processes seem to be feasible, but largescale production has not yet been possible. Polylactic acidmass production, processing, industrial. Scientific literature regarding lactic acid production from lignocellulosic materials mainly reports utilization of the cellulosic fraction, since just few strains are capable of consuming hemicellulose. Scheele in sour milk, and in 1881 fermi obtained lactic acid by fermentation, resulting in its industrial production. Also, cull potatoes, the unacceptable version of potato tubers, cannot support the growth of l. In the last few decades, the production of lactic acid has substantially increased primarily because of the development.
Whether you want an acidulant for leather and textile production, a chelating agent for electroless plating or a replacement for acetic, formic or citric acids, our natural solutions deliver for you. This limitation can be overcome by blending polyd and polyllactic acid. Polylactic acid pla is the biodegradable polymer of lactic acid, which is produced via fermentation processes. Microbial production effectively competes with chemical synthesis methods because biochemical synthesis permits. Pdf lactic acid is one of the most commercially useful hydroxycarboxylic acids.
Continuous fermentation in the production of lactic acid. When both added in equal quantity to form a mixture is known as dl lactic acid, 4. Pla is an aliphatic polyester, primarily produced by industrial polycondensation of lactic acid andor ringopening polymerization of lactide. Lactic acid production from sugarcane bagasse hydrolysates by. Lactic acid is excreted to levels that inhibit competing bacteria, which happen to be the undesirable types for humans. Full article lactic acid production to purification. Lactic acid is an important platform chemical with a wide range of applications. We invite you to browse our wizard to help choose the best solution to answer your needs. The yearly world lactic acid production is expected to reach 259,000 metric tons by the year 2012. Lactic acid production, product is distilled to get aqueous solution of lactic acid and distilled product is methanol. Acetic acid acetic acid ch3 cooh, molecular weight of 60.
In particular, the capsular polysaccharides and exopolysaccharides have been implicated in modulation of the rheological properties of fermented products. Optimization of medium composition 29 brazilian journal of chemical engineering vol. Heterofermentative bacteriaproduce other byproducts, besides lactic acid, and therefore are not useful for industrial production of lactic acid. Apr 06, 2015 production of lactic acid and acidic acid 1. A simple method to reduce both lactic acid and ammonium. The process, illustrated in figure 6, is a continuous process. An article explaining about the current processes of lactic acid production both via chemical precursor and organic precursor. Industrial production of acetone, butanol, butanodiol substrates for rubber production 1 1930 discovery of biotechnological method of organic acids production citric and gluconic acid 1, 5 1940s industrial production of organic acids 1 1950s industrial penicillin production. Cargill awarded for innovation in lactic acid production. There are disclosed methods for producing lactic acid that comprise fermentation of a sugar to produce a lactate, optionally a salt swapping process to produce an ammonium lactate or akyl ammonium lactate, an extractive salt splitting process to produce a lactic acid loaded extractant, and separation of lactic acid by water back extraction or by direct distillation. The global lactic acid marketsize was valued at usd 2. Lactic acid fermentation 3 sauerkraut lactic acid fermentation is also used in the production of sauerkraut. Homofermentative production of optically pure llactic.
In the chemical industry, lactic acid can be converted to ethanol, propylene glycol, and acrylic polymers. Lactic acid is a relatively cheap product, and one of the major challenges in its largescale fermentative production is the cost of the raw material. Lactic acid industrial production lactic acid fructose. This organic acid was firstly produced in industrial scale in 1895 by the famous chemicalpharmaceutical. Jan 22, 2015 adachi e, torigoe m, sugiyama m, nikawa ji, shimizu k 1998 modification of metabolic pathways of saccharomyces cerevisiae by the expression of lactate dehydrogenase and deletion of pyruvate decarboxylase genes for the lactic acid fermentation at low ph value. Industrial production of lactic acid request pdf researchgate. Lactic acid production by new lactobacillus plantarum. Industrial production of llactic acid, which in polymerized form as polylactic acid is widely used as a biodegradable plastic, has been attracting worldwide attention. Fermentation processes for the production of lactic acid. This limitation can be overcome by blending polyd and polyl lactic acid.
Lactic acid witnessed significant attention on account of being a monomer for the manufacturing of biodegradable polylactic acid and is usually manufactured either through chemical synthesis or biotechnological fermentation. On an industrial scale, the targeted manufacturing cost of the lactic acid monomer is less than 0. The development of economical production routes and a rising environmental awareness by the general public have pushed pla uses to new markets, including. The name of lactic acid was derived from the latin name lact which means milk. Production of racemic lactic acid consisting of a 1.
Lactic acid has been produced on an industrial scale since the end of the nineteenth century and is mainly used in the food industry to. Adachi e, torigoe m, sugiyama m, nikawa ji, shimizu k 1998 modification of metabolic pathways of saccharomyces cerevisiae by the expression of lactate dehydrogenase and deletion of pyruvate decarboxylase genes for the lactic acid fermentation at low ph value. Fermentation processes that involve the production of acetic and lactic acid have been used in food preparation for centuries. The main type of bacteria used in the production of sauerkraut is of the genus leuconostoc. Biotechnological production of lactic acid and its recent applications. Lactic acid has been an intermediatevolume specialty chemical world production 50,000 tonsyr used in a wide range of food processing and industrial applications.
However, the role of lactic acid bacteria on the production of lactic acid was first reported by the famous french scientist louis pasteur. Lactic acid bacteria lab play a critical role in food production and health maintenance. When both added in equal quantity to form a mixture is known as dllactic acid, 4. Journal of chemical and pharmaceutical research, 2015, 710. Production and purification of llactic acid in lab and pilot. Lactic acid is an important commodity chemical having a wide range of applications. Production, properties, and industrial food application of. Worldwide lactic acid production from microbial fermentation accounts for around 90% of the total lactic acid production hofvendahl and hahnhagerdal 2000 and has attracted interest because of its numerous advantages compared with chemical synthesis, such as production of pure isomers and the use of renewable resources as fermentation. For instance, lactate is constantly produced and eliminated during normal metabolism and physical exercise. Industrial scale production of dlactic acid by fermentation is possible, but much more challenging. There is large variability in eps production by lab in terms of chemical composition, quantity, molecular size, charge, presence of side chains, and rigidity of the. Food industrial wastes, high in moisture and rich in carbon source have been considered as an attractive nutrient source for industrial lactic acid production, which is a cheaper substrate as a source of sugars to be utilized in a fermentation process subsequently for lactic acid production rashid and altaf 2008.
Lactic acid fermentation 1 lactic acid fermentation one isomer of lactic acid this is presented to you by tatsa wambea landry. There is an increasing interest in these species to reveal the many possible health benefits associated with them. Lactic acid bacteria are allowed to ferment and acidify these foodstuffs by producing lactic acid. Microbial production of organic acids is a promising approach for obtaining buildingblock chemicals from renewable carbon sources. The carboxylate platform is comprised of biological and chemical pathways that can be used in order to convert waste to bioproducts, such as lactic acid. Help us write another book on this subject and reach. Production of organic acids encyclopedia of life support.